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大腸腺腫発症モデルマウスにおける食餌性ナガイモおよびナガイモ入り青汁の効果 OAK
木下, 幹朗; 柚木, 恵太; 得字, 圭彦; 川原, 美香; 大庭, 潔; 弘中, 和憲; 大西, 正男; Kinoshita, Mikio; Yunoki, Keita; Tokuji, Yoshihiko; Kawahara, Mika; Ohba, Kiyoshi; Hironaka, Kazunori; Ohnishi, Masao.
食餌性ナガイモの大腸腺腫発症に与える効果を他のイモ類と比較しつつ,1,2-ジメチルヒドラジン投与マウスを用いて調べるとともに,ナガイモを利用した商品モデル(ナガイモ入り青汁)の効果についても検証した.その結果,ナガイモ以外のイモ類においても上記の実験動物モデルにおいて大腸腺腫抑制効果が観察されたが,腺腫数の平均はナガイモ群が一番低かった.また,商品モデルであるナガイモ入り青汁ついても腺腫抑制効果が観察された.The dietary effects of Chinese yam,nagaimo (Dioscorea opposita Thunb.),on 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) formation in the large intestine of mice were investigated and compared with those of other potato species. Potato consumption was found to significantly suppress ACF formation in the large intestines of all mice treated with DMH. Suppression of ACF formation was most remarkable in the nagaimo group. Moreover, the commercial product (aojiru) containing nagaimo powder also suppressed ACF formation.
Palavras-chave: ナガイモ 大腸腺腫 大腸ガン 1; 2-ジメチルヒドラジン 青汁 Chinese yam (nagaimo) aberrant crypt foci colon cancer 1; 2-dimethylhydrazine leaf juice (aojiru).
Ano: 2009 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2709
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Promotive Effects of the Dietary Organic Germanium Poly-trans-[(2-carboxyethyl) germasesquioxane] (Ge-132) on the Secretion and Antioxidative Activity of Bile in Rodents OAK
Nakamura, Takashi; Nagura, Taizo; Akiba, Mitsuo; Sato, Katsuyuki; Tokuji, Yoshihiko; Ohnishi, Masao; Osada, Kyoichi; 得字, 圭彦; 大西, 正男.
http://www.pharm.or.jp/jhs.html
Palavras-chave: Poly-trans-[(2-carboxyethyl) germasesquioxane]; Bilirubin; Bile acid; Uridine diphosphate glucuronosyltransferase 1a1; Organic germanium.
Ano: 2010 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3598
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Invariant Vα14 Natural Killer T Cell Activation by Edible Mushroom Acidic Glycosphingolipids OAK
NOZAKI, Hirofumi; ITONORI, Saki; SUGITA, Mutsumi; NAKAMURA, Kimihide; OHBA, Kiyoshi; OHNISHI, Masao; IMAI, Kunitoshi; IGARASHI, Yasuyuki; SUZUKI, Akemi; KUSHI, Yasunori; 中村, 公英; 大西, 正男; 今井, 邦俊.
https://www.jstage.jst.go.jp/article/bpb/33/4/33_4_580/_article
Palavras-chave: Alpha-galactosylceramide; Glycosphingolipid; Edible mushroom; Natural killer T cell; Mouse.
Ano: 2010 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3599
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Oleanolic Acid and Ursolic Acid in Commercial Dried Fruits OAK
ZHANG, Feng; DAIMARU, Eisuke; OHNISHI, Masao; KINOSHITA, Mikio; TOKUJI, Yoshihiko; 得字, 圭彦.
Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have preventive properties such as anti-tumor and anti-hepatitis activities. These triterpenes are known to exist in several medicinal plants and fruit skins. Dried fruits are usually eaten without removing the skin; thus, they may be good resources for oral intake of OA and UA. HPLC analysis of OA and UA contents in a variety of dried fruits showed that raisins contained higher levels of OA than the other fruits investigated, with green raisins containing the highest levels (79.0 mg/100 g). While raisins were found to contain only OA, dried cranberries, blueberries and cherries were shown to contain both OA and UA. The highest level of UA (65.9 mg/100 g) was detected in cranberries,...
Palavras-chave: Oleanolic acid; Ursolic acid; Dried fruits; Raisins; Cranberries.
Ano: 2013 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3902
Registros recuperados: 24
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